Alexis Madrigal is a senior editor at The Atlantic. He's the author of Powering the Dream: The History and Promise of Green Technology.
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There are some people who love machines the way some people love food. They fix things. They build things. They repair things. If you want your children to be this type of person, you may want to check out the wonderful new project that Lucas Ainsworth and Alyssa Hamel have up on Kickstarter.
Kinetic Creatures is a set of three cardboard animals that you assemble yourself. They don't just stand there, though: they walk! You can use human power or a little motor to send them on their way.
They are simple but also complex. They are crafty but also manufactured. They are real, but will only become available if enough people pool their money to bring them into being. These are creatures of our time.
Via Joe Moon


After a weird IPO, no one knows exactly what's going to happen with the social media's shares on its first full day of trading.

Many tech twitterers thought the company's first day on the market would go a lot better than it did.


I do not think that I can add anything to this video, but I would like to thank its creators, who have brought so much joy to me on this day. "Most of the people in this video have never met face to face," the video maintains. "We are a global family of people committed to inspiring and empowering each other via Facebook."
Don't miss the song's Facebook page, either.
OK, I do have one thing to say about this video. This is a celebrity singalong from our universe in which everyone sort of behaves like a celebrity. It's "We Are the World" multiplied by The Cult of the Amateur and raised to the power of Facebook's opening-day share price.
Via @normative


A preview of what the next wave of anti-corporate activism might look like. Call it Big Dada: speaking noise to power.

The unlikely story of a company that built a business selling the recent torrent of digital photos.

Even the most cherished skills for manipulating our machines eventually lose their utility.
At some point in the not-too-distant past, the key technological moment in a teenager's life might have been when she learned how to depress the clutch with her left foot, change her car's gear with her right hand, while giving the engine gas with her right foot. As the driver improved, the action became automatic and if you were a particular kind of dumb, rural teenager (like myself), you may have tried to see how fast you could get your car going in a given direction. The keys to this (I may have discovered) are when and how you shift the gears. I felt much mildly unsafe joy in getting from 0 to 60 as quickly as possible in my little Ford Escort.While climate change may be complex and difficult terrain, rediscovering our industrial infrastructure is compelling.

A coal mine in Utah (Reuters).
The Rio+20 UN summit is just around the corner, the latest in a decades-long string of international meetings that attempt to address one of the world's greatest and most global environmental problems.What's that? Your eyes have already glazed over? Well, you're not alone. I just spent the last couple of days in Seoul for the Global Green Growth Institute Summit, where I spoke during a session on green journalism. A common refrain from both the speakers and the audience was that that people were
tired of hearing the same jeremiads about greenhouse gas concentrations, sea level rise, and government panels. Even people who care deeply about the environment are fatigued. This is a particularly acute problem on the
Internet where the distribution of a story largely depends on readers to share the narrative with their friends through social media. The standard climate change narratives are not shareable.
But to me the most interesting stories to tell about climate change have never been attempts to elucidate the worst-case scenarios. As an organizing narrative, what climate change offered me was a reason to rediscover and reimagine the world's basic infrastructure. Want to radically improve the efficiency of the transportation system? Well, first you have to understand how and why Americans built the system that we have. You have to ask: What problems were our forebears trying to solve?
For people who grew up in the 1980s and 1990s, this is a fascinating topic because we came into a world that had effectively covered its tracks. By the
logic of the system, making the industrial processes that power the world opaque was good, so we don't see them in our daily lives. As an early 21st century American, it is easy to be completely ignorant of the basic systems -- food, water, energy -- that make modern life possible. You just don't have to know.
I think there's a perception that people don't want to read stories about the innards of industrial life, but I've never had a hard time getting people to look at and share these narratives. Take a look at Reddit's Today I Learned section. Among the miscellany, you often find factlets about how the 20th century's big technological systems work. Which makes sense because there is just so much to know about the complex networks that deliver what we need. When you really think about everything that needs to happen for a piece of coal in Wyoming to become the electricity that flows into your phone, it's stunning. It doesn't make me mad or depressed, even though burning the coal emits carbon. Rather, I'm filled with awe about the achievements of previous generations, and maybe with some hope that our generation can accomplish something equally ambitious.
Readers aren't stupid. They know when your product is cheap.

Just one more pebble of evidence on a growing pile that Silicon Valley has been too focused on small ideas in the social space.
In a blog post today, an early investor in the warehouse robot company, Kiva, detailed what he learned from the venture.
If you haven't been watching the logistics space, Kiva makes squat little robots that work in vast teams in e-commerce fulfillment centers. Instead of humans wandering into vast stacks of merchandise, robots bring that merchandise to the workers. The robots carry out the work according to constantly evolving algorithms that maximize the efficiency of the operation.
They are a very big idea in logistics -- and one that founder Mick Mountz built a company around that Amazon purchased for $775 million in a deal that closed this week.
In today's blog post, Ajay Agarwal of Bain Capital Ventures noted that Mountz was unable to find funding in Silicon Valley, despite the idea's now-fulfilled promise.
There have been several blog posts, most notably by Peter Thiel and Founders Fund, discussing the venture community's lack of desire to fund transformational companies -those with disruptive technologies taking on big problems. Mick saw this firsthand. When Mick first started Kiva shortly after the bubble burst, he was unable to raise funding on Sand Hill Road. This ultimately caused him to move to Boston, where he raised his angel round and eventually his round from Bain Capital Ventures...The truth is, Kiva simply wasn't a company that could be cranked out in weeks with some seed money, and the technical obstacles inherent in building a solution like this forced Kiva to invest years working on the solution pre GA. However, once they built a working and viable solution, they had the advantage of significant IP and few direct competitors.
There are echoes in Agarwal's post of the no-idea-too-small attitude that I discussed in my recent essay, "The Jig Is Up: Time to Get Past Facebook and Invent a New Future."
A small group of dolphins in Brazil have learned to steer fish into humans' nets, but no one knows why.
Even more intriguingly, only a subgroup of the 50 or so dolphins have picked up the human habit. A third help out, while the rest steer clear of the people. Why do some dolphins help out? And why do others avoid the behavior?Every autumn, lucky visitors to Laguna, Brazil, which is situated around a narrow lagoon on the Atlantic Ocean, catch an odd sight. Here, resident bottlenose dolphins (Tursiops truncatus) frequently turn sheepdog, herding schools of small, silver fish called mullets toward the shore--and, it turns out, toward lines of wading fishers. As soon as the dolphins get close to their human companions, they give the signal, slapping their heads or tails against the surf. In an instant, the fishers cast their nets, catching dozens of frenzied mullet.

A pioneering ship proves a point about the possibilities of renewable energy.




Dairy scientists are the Gregor Mendels of the genomics age, developing new methods for understanding the link between genes and living things, all while quadrupling the average cow's milk production since your parents were born.

Reuters.
While there are more than 8 million Holstein dairy cows in the United States, there is exactly one bull that has been scientifically calculated to be the very
best in the land. He goes by the name of Badger-Bluff Fanny Freddie.
Already, Badger-Bluff Fanny Freddie has 346 daughters who are on the books and thousands more that will be added to his progeny count when they start producing milk. This is quite a career for a young animal: He was only born in 2004.
There is a reason, of course, that the semen that Badger-Bluff Fanny Freddie produces has become such a hot commodity in what one artificial-insemination company calls "today's fast paced cattle semen market." In January of 2009, before he had a single daughter producing milk, the United States Department of Agriculture took a look at his lineage and more than 50,000 markers on his genome and declared him the best bull in the land. And, three years and 346 milk- and data-providing daughters later, it turns out that they were right.
"When Freddie [as he is known] had no daughter records our equations predicted from his DNA that he would be the best bull," USDA research geneticist Paul VanRaden emailed me with a detectable hint of pride. "Now he is the best progeny tested bull (as predicted)."
Data-driven predictions are responsible for a massive transformation of America's dairy cows. While other industries are just catching on to this whole "big data" thing, the animal sciences -- and dairy breeding in particular -- have been using large amounts of data since long before VanRaden was calculating the outsized genetic impact of the most sought-after bulls with a pencil and paper in the 1980s.
Dairy breeding is perfect for quantitative analysis. Pedigree records have been assiduously kept; relatively easy artificial insemination has
helped centralized genetic information in a small number of key bulls since the 1960s; there are a relatively small and easily measurable number of traits --
milk production, fat in the milk, protein in the milk, longevity, udder quality -- that breeders want to optimize; each cow works for three or four
years, which means that farmers invest thousands of dollars into each animal, so it's worth it to get the best semen money can buy. The economics push breeders to use the genetics.
The bull market (heh) can be reduced to one key statistic, lifetime net merit, though there are many nuances that the single number cannot capture. Net merit denotes the likely additive value of a bull's genetics. The number is actually denominated in dollars because it is an estimate of how much a bull's genetic material will likely improve the revenue from a given cow. A very complicated equation weights all of the factors that go into dairy breeding and -- voila -- you come out with this single number. For example, a bull that could help a cow make an extra 1000 pounds of milk over her lifetime only gets an increase of $1 in net merit while a bull who will help that same cow produce a pound more protein will get $3.41 more in net merit. An increase of a single month of predicted productive life yields $35 more.
When you add it all up, Badger-Fluff Fanny Freddie has a net merit of $792. No other proven sire ranks above $750 and only seven bulls in the country rank above $700. One might assume that this is largely because the bull can help the cows make more milk, but it's not! While breeders used to select for greater milk production, that's no longer considered the most important trait. For example, the number three bull in America is named Ensenada Taboo Planet-Et. His predicted transmitting ability for milk production is +2323, more than 1100 pounds greater than Freddie. His offspring's milk will likely containmore protein and fat as well. But his daughters' productive life would be shorter and their pregnancy rate is lower. And these factors, as well as some traits related to the hypothetical daughters' size and udder quality, trump Planet's impressive production stats.
One reason for the change in breeding emphasis is that our cows already produce tremendous amounts of milk relative to their forbears. In
1942, when my father was born, the average dairy cow produced less than 5,000 pounds of milk in its lifetime. Now, the average cow produces over 21,000 pounds of
milk. At the same time, the number of dairy cows has decreased from a high of 25 million around the end of World War II to fewer than nine
million today. This is an indisputable environmental win as fewer cows create less methane, a potent greenhouse gas, and require less land.
At the same time, it turns out that cow genomes are more complex than we thought: as milk production amps up, fertility drops. There's an art to balancing all the traits that go into optimizing a herd.
While we may worry about the use of antibiotics to stimulate animal growth or the use of hormones to increase milk production by up to 25 percent, most of the increase in the pounds of milk an animal puts out over the pastoral days of yore come from the genetic changes that we've wrought within these animals. It doesn't matter how the cow is raised -- in an idyllic pasture or a feedlot -- either way, the animal of 2012 is not the animal of 1940 or 1980 or even 2000. A group of USDA and University of Minnesota scientists calculated that 22 percent of the genome of Holstein cattle has been altered by human selection over the last 40 years.
In a sense that's very real, information itself has transformed these animals. The information did not accomplish this feat on its own, of course. All of this technological and scientific change is occurring within the social context of American capitalism. Over the last few decades, the number of dairies has collapsed and the size of herds has increased. These larger operations are factory farms that are built to squeeze inefficiencies out of the system to generate profits. They benefit from economies of scale that allow them to bring in genomic specialists and use more expensive bull semen.
No matter how you apportion the praise or blame, the net effect is the same. Thousands of years of qualitative breeding on family-run farms begat cows producing a few thousand pounds of milk in their lifetimes; a mere 70 years of quantitative breeding optimized to suit corporate imperatives quadrupled what all previous civilization had accomplished. And the crazy thing is, we're at the cusp of a new era in which genomic data starts to compress the cycle of trait improvement, accelerating our path towards the perfect milk-production machine, also known as the Holstein dairy cow.
***

A botanical drawing of Mendel's pea plants. The Field Museum.
There are no more famous experiments in genetics than the ones undertaken by the Austrian monk Gregor Mendel on five acres in what is now the Czech
Republic from 1856 to 1863. Mendel bred 29,000 pea plants and discovered the most basic rules of genetics without any knowledge of the underlying
biochemical mechanics.
Smack dab in the middle of Mendel's experiments, Charles Darwin's Origin of Species was published, but we don't have any record of intellectual mingling between the two men. Even the idea of a gene as an irreducible unit of inheritance wasn't presented until 30 years after Mendel began his experiments. The term and field of genetics would not be fleshed out until William Bateson and company came along in the early 1900s. And its form, DNA, would not be proposed by James Watson and Francis Crick with indispensable help from Rosalind Franklin until 90 years after his last pea plant died. All this to say: Mendel was ahead of his time.
Here's the simple version of what he did. Mendel took pea plants that reliably produced purple or white flowers when they self-pollinated. Then he crossbred them, carefully controlling how the plants reproduced. Now, one might expect that if you breed a pea plant with a purple flower and a pea plant with a white flower, you'd get progeny that were sort of mauve, a mix of the two colors. But what Mendel found instead is that you either got purple flowers or white flowers. Even more amazingly, sometimes breeding two purple flowers would yield a white flower. Among the first generation of crossbreeds, the mix of flower colors occurred at a roughly constant ratio of about 3:1, purple to white. If the traits of two plants were being mixed to generate the next generation, how could two purple flowers yield a white flower? And why would this ratio arise?
Mendel took a conceptual leap and hypothesized that the plants had two possible copies of its plans (i.e. genes) to make flower color (or any of six other traits he analyzed). If the plant received two of the dominant plan (purple), the flowers would, of course, be purple. If it received one of each, the dominant plan would still reign. But if the plant received two recessive plans, then the flowers of that pea would be white.
The monk turned out to be right. For traits controlled by a single gene, things really do work as he predicted. Mendel's insights became part of the central dogma of genetics. You can use the statistical method he used to calculate how likely someone is to get sickle cell anemia from her parents. In most genetics classes, Mendel is where it all starts and for good reason.
But it turns out that Mendel's version of things doesn't actually give a very clear picture of the kinds of things we care about most. "Mendel studied a few traits that happened to be controlled by a single gene, making the probabilities easier to figure out," the USDA's VanRaden said. "Animal breeders for many decades have used models that assume most traits are influenced by thousands of genes with very small effects. Some [individual] genes do have detectable effects, but many studies of plant and animal traits conclude that most of the genetic variation is from many little effects."
For dairy cows -- or humans, for that matter -- it's just not as simple as the dominant-recessive single-gene paradigm that Mendel created. In fact, Mendel picked his model organism well. Its simplicity allowed him to focus in on the simplest possible genetic model and figure it out. He could easily manipulate the plant breeding; he could observe key traits of the plant; and these traits happened to be controlled by a single gene, so the math lay within human computational range. Pea plants were perfect for studying the basics of genetics.
With that in mind, allow me to suggest, then, that the dairy farmers of America, and the geneticists who work with them, are the Mendels of the genomic age. That makes
the dairy cow the pea plant of this exciting new time in biology. Last week in the Proceedings of the National Academy of Science, two of the most
successful bulls of all time had their genomes published.
This is a landmark in dairy herd genomics, but it's most significant as a sign that while genomics
remains mostly a curiosity for humans, it's already coming of age when it comes to cattle. It's telling that the cutting-edge genomics company Illumina
has precisely one applied market: animal science. They make a chip that measures 50,000 markers on the cow genome for attributes that control the
economically important functions of those animals.

A snippet from Illumina's animal science fact sheet.
***
Mendel may have worked with plants, the rules he revealed turned out to be universal for all living things. The same could be true of the statistical
rules that dairy scientists are learning about how to match up genomic data with the physical attributes they generate. The statistical rules that reflect the way dozens or hundreds of genes come together to make a cow likely to develop mastitis, say, may be formally similar to the rules that govern what makes people susceptible to schizophrenia or prone to living for a long time. Researchers like the University of Queensland's Peter Visscher are bringing the lessons of animal science to bear on our favorite animal, ourselves.
Want to live for a very long time? Well, we hope to discover the group of genes that are responsible for longevity. The problem is that you have genomic data over here and you have phenotypic data, i.e. how things actually are, over there. What you need, then, is some way of translating between these two realms. And it's that matrix, that series of transformations, that animal scientists have been working on for the past decade.
It turned out they were in the perfect spot to look for
statistical rules. They had databases of old and new bull semen. They
had old and new
production data. In essence, it wasn't that difficult to
generate rules for transforming genomic data into real-world predictions.
Despite -- or because of -- the effectiveness of traditional
breeding techniques, molecular biology has been applied in the field for
years in different ways. Given that breeders were trying to discover
bulls' hidden genetic profiles by evaluating the traits in their offspring that could be measured,
it just made sense to start
generating direct data about the animals' genomes.
"Each of the bulls on the sire list, we have 50,000 genetic markers. Most of those, we have 700,000," the USDA's VanRaden said. "Every month we get another 12,000 new calves, the DNA readings come in and we send the predictions out. We have a total of 200,000 animals with DNA analysis. That's why it's been so easy. We had such a good phenotype file and we had DNA stored on all these bulls."
They had all that information because for decades, scientists have been taking data from cows to
figure out which bulls produced the best offspring. Typically, a bull
with a
promising pedigree would reach sexual maturity and his semen
would be used to impregnate a selection of about 50 test cows. Those
daughters would grow
up and start producing milk a few years later. The data from
those cows would be used to calculate the value of that now "proven"
bull. People called the process
"progeny testing" and it did not require that breeders knew the
exact genetic makeup of a bull. Instead, scientists and breeders could
simply say: We
do not know the underlying constellations of genes that make
this bull so valuable, but we do know how much milk his kids will
produce. They learned to
use that data to predict who the best bulls were.
That meant that some bulls became incredibly sought after. The number two bull of the last century, Pawnee Farm Arlinda Chief, had more than 16,000 daughters, 500,000 granddaughers, and 2 million great granddaughters. He's responsible for about 14 percent of all the genetic material in all Holsteins, USDA scientists estimate.
"[In the past], we combined performance data -- milk yield, protein yield, confirmation data -- with pedigree information, and ran it through a fairly sophisticated computing gobbledygook," another USDA scientist Curt Van Tassel told a group of dairy farmers. "It spit out at the other end predicted transmitting ability, predicted genetic values of whatever sort. Now what we're trying to do is tweak that black box by introducing genomic data."
There are many different ways you could model the mapping of 50,000 genetic markers onto a dozen performance traits, especially when you have to consider all kinds of environmental factors. So the dairy breeders have been developing and testing statistical models to take all this stuff into account and spit out good predictions of which bulls herd managers should ultimately select.The real promise is not that genomic data will actually be better than the ground-truth information generated from real offspring (though it might be), but rather that the estimates will be close enough to real but save 3 to 4 years per generation. If you don't have to wait for daughters to start cranking out milk, then you can shave those years off the improvement cycle, speeding it up several times.
Nowadays breeders can choose between "genomic bulls," which have
been evaluated based purely on their genes and "proven bulls," for
which real
world data is available. Discussions among dairy breeders show
that many are beginning to mix in younger bulls with good-looking
genomic data into the
breeding regimens. How well has it gone? The first of the bulls who were bred from their genetic profiles alone, are receiving their initial production data. So far, it
seems as if the genomic estimates were a little high, but more accurate than traditional methods alone.
The unique dataset and success of dairy breeders now has other scientists sniffing around their findings. Leonid Kruglyak, a genomics professor at
Princeton, told me that "a lot of the statistical techniques and methodology" that connect phenotype and genotype were developed by animal breeders. In
a sense, they are like codebreakers. If you know the rules of encoding. it's not difficult to put information in one end and have it pop out the other
as a code. But if you're starting with the code, that's a brutally difficult problem. And it's the one that diary geneticists have been working on.
Their work could reach outside the medical realm to help us understand human's evolution as well. For example, Kruglyak said, human population geneticists want to figure out how to explain the remarkable lack of genetic variance between human beings. "The typical [genetic] variation among humans is one change in a thousand," he said. "Chimps, though they obviously have a much smaller population now, have several fold higher genetic diversity." How could this be? Researchers hypothesize that human beings once went through a bottleneck where there were very few humans relative both to the current human population and the chimp population. Few humans meant that the gene pool was limited at some point in the pre-historical but fairly recent past. We've never recovered the diversity we might have had.
***

The number-one ranked bull in the world. Kathy DeBruin.

So, Peretti told me that he considers a BuzzFeed list -- its sequencing, framing, etc -- to be a transformative use of photos. That is to say, including that unattributed photo of the otter in that list was OK because its inclusion as an "extremely disappointed" animal transformed the nature of the photo.
To justify the use as fair, one must demonstrate how it either advances knowledge or the progress of the arts through the addition of something new. A key consideration is the extent to which the use is interpreted as transformative, as opposed to merely derivative.
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